PRP – Rational/Indication Does current clinical evidence support the use of PRP for knee OA For which degrees of knee OA is PRP best indicated? Can PRP be used in severe knee OA (KL4)? Is PRP indicated for the treatment of Patellofemoral OA (PFOA)? Are there specific contraindications for the use of PRP for knee… Continue reading ORthoBIologics InitiaTive (ORBIT) Consensus from ESSKA – Section 1
In April 2022, following the annual ESSKA congress, a group of experts published an important document stating their recommendations on the use of PRP in the management of knee osteoarthritis. This is a consensus paper which was obtained after more than 2 years of deliberations on the subject, answering 28 specific questions for which an… Continue reading ORthoBIologics InitiaTive (ORBIT) Consensus from ESSKA
Platelet-Rich Plasma in Female Androgenetic Alopecia: A Comprehensive Systematic Review and Meta-Analysis In this work, Zhou et al.3 summarize different treatment regimes in female androgenetic alopecia (AGA), and quantitively analyze the efficacy of PRP in this disease. They evaluated 636 studies and 12 trials from six databases (MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled… Continue reading Study: Female Androgenetic Alopecia
Platelet-Rich Plasma in The new Medical Devices Regulation (2017/745/EU), applicable since May 2021 in EU, will replace the existing Medical Devices Directives (93/42/EEC). This regulation provides a framework for the manufacture, modification, and use of devices when equivalent devices are not commercially available (Article 5 of the Medical Device Regulation). In these situations, health care… Continue reading New Medical Device Regulation
Platelet concentration is the number of platelets per unit of volume. Usually, platelet concentration is expressed in millions per ml. The platelet concentration factor is the ratio between platelet concentration in PRP and baseline platelet concentration in whole blood and is generally expressed as nX, where n is the value of ratio. When all platelets… Continue reading Platelet concentration & concentration factor
Autologous regenerative stimulants for bone allograft implantation In their report, Vorobyov et al. present a clinical case where a combination of allogeneic osteoplastic materials with autologous platelet-rich plasma is used to reconstruct a cavity defect in the tibia. Firstly, the authors describe the basic principles of orthobiology and the different surgical techniques for bone reconstruction using bone… Continue reading Study: Orthopedic surgery
European Standard EN 16844:2017+A2 (August 2019) The European Standard EN 16844:2017+A2 defines the set of requirements deemed essential for the delivery of aesthetic medicine services (non-surgical medical treatments). This European Standard was adopted by the European Committee for Standardization (CEN) on December 20, 2017 and includes Amendment 2 adopted by CEN on April 16, 2019.… Continue reading Regulatory update : European Standard
Knee osteoarthritis: Intra-Articular Injections of Platelet-Rich Plasma, Adipose Mesenchymal Stem Cells, and Bone Marrow Mesenchymal Stem Cells Associated with Better Outcomes Than Hyaluronic Acid and Saline The purpose of this work was to perform a network meta-analysis to evaluate clinical efficacy and treatment-related adverse events (AEs) of intra-articular hyaluronic acid (HA), leukocyte-poor platelet-rich plasma (LP-PRP), leukocyte-rich… Continue reading Meta-analysis: Rheumatology
Stretch marks: In vitro study and assessment of combined treatment with PRP and sodium ascorbate on fibroblasts
What is important to note for the preparation of Platelet-Rich Plasma (PRP) with respect to the new* MDR (Medical Device Regulation) 2017/745
